An avalanche slid during the night, scarring a streak of debris on the slope a quarter-mile from camp.
It is entirely possible that she sustained such significant injuries and scarring during her first delivery that she was unable to conceive or carry to term again.
Ed's vacant face as he salutes during Scar's song, Be Prepared, is an image that still makes me smile at random moments in life.
MMPs were initially thought to only function in the resolution phase of wound healing, particularly during scar resorption; however, recent evidence suggests that they also influence other wound-healing responses, such as inflammation and re-epithelialization.
The neurogenic response of cardiac nestin cells during scar formation/healing was inhibited following the superimposition of type I diabetes.
Elevated levels of HA are synthesized during scar-free fetal tissue repair and the prolonged presence of HA assures such scar-free tissue repair.
Galectin-1 has been detected in comparatively high concentrations in the stroma of squamous cell carcinomas and in healing wounds, with its activity increasing during scar formation [ 34].
Moreover, microarray analyses on RNA of macrophages isolated from infarcted tissues confirmed the expression of proinflammatory (M1) markers in the tissue early after injury and of alternative activated (M2) macrophage markers later during scar tissue formation [ 23].
Not only is CTGF overexpressed during scar formation, but it is also required for persistent TGF- β-driven fibrosis, as seen in a mouse fibrosis model where CTGF inhibition has been shown to prevent and reverse fibrosis [ 15].
Vitronectin stimulates dermal healing (Jang et al, 2000), is transiently upregulated during scar formation, and has been identified as a marker of hepatic fibrosis (Koukoulis et al, 2001; Montaldo et al, 2014).
The authors provide evidence that a large portion of the myofibroblasts exhibiting canonical Wnt signaling activity that accumulate in the injury area during scar tissue formation are endothelial derived.
