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Gro interacts with hypoacetylated histones, suggesting the possibility that it uses deacetylated histones as a platform to spread across a gene during repression.
Moreover, importantly, we observed that the introduction of H3K9me1 during repression required DNA replication.
Our results add to our understanding of Maf1 localization during repression of Pol III.
The distinct chromatin changes observed in the RP genes during repression can be explained only if both osmotic and diamide stresses operate via distinct pathways.
On the other hand, emerging evidence suggests that PERs binding might interfere with complex formation between CRYs and CLOCK-BMAL1 at certain steps during repression (Ye et al., 2011; Akashi et al., 2014).
Cdk9 has been reported to have other targets, such as the kinase-independent actions of Cdk9 during repression of B-Myb transactivation activity (27) and in transcriptional elongation once the pol II complex is released from the pause site.
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However, these authors also found that the H3K4me3 levels increased at the 5′ ends of a substantial number of diamide-repressed genes during their repression, including RP genes [ 63], which clearly contradicts our results.
"Those like Francis that remained in silence during the repression also played by default a central role," he said.
Munyaka is one of 40,000 Kenyans who are suing the UK government for compensation over the injuries and losses suffered during official repression of the Mau Mau insurgency.
It was primarily through the efforts of his widow, who died in 1980, that little of Mandelshtam's poetry was lost; she kept his works alive during the repression by memorizing them and by collecting copies.
A group of elderly Kenyans allegedly tortured and assaulted during the repression of their country's independence movement in the 1950s is to present a letter to No 10 tomorrow morning calling on the British government to launch an investigation into their treatment.
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