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Specific T-cells are localized to ganglia during the chronic phase of HSV infection and to several infected areas during recurrences, and persist long after viral clearance.
To explain these findings, we developed a stochastic spatial model that accurately reproduces empirically derived episode rate, duration, early viral expansion, late viral decay rate, and viral re-expansion frequency, as well as serpiginous spatial distribution of viral ulcers during recurrences.
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Furthermore, Watzke et al. described that serous RPE detachments occurred either at the first appearance of a new lesion or during recurrence [1].
Because CSCs have been proposed to be the key tumor-initiating cell during recurrence, researchers have looked at chemoresistance as a functional mechanism by which one can identify and isolate CSCs.
The patients were not on azole antifungal treatment at time of enrollment; subsequent samples were collected during recurrence of infection.
Using this model, we first applied analytical tools to characterize rebound growth kinetics of the tumor during recurrence.
Analyses of eight additional cases further confirmed that SP compositions invariably change with recurrence and that SP dynamics during recurrence are highly individualized.
There is a wider spread of OPN values above the median in samples measured during recurrence (Period 2) in the 80 patients who experienced recurrence (Group F).
The prognostic abilities of p53 expression during recurrence after intravesical BCG therapy were investigated, but conflicting results were obtained [ 17, 19– 22, 36, 37, 42– 42].
According to their findings, trastuzumab is effective in clearing HER-2-positive cells from the BM during recurrence-free follow-up of BC patients.
Because TICs are thought to be important in tumourigenesis during transition from the pre-malignant stage to the malignant stage or during recurrence with a few tumour cells, this model should be useful for monitoring tumourigenesis at these stages.
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