Both play only five games against Top 4 teams from last year (fewest in the NRL) along with just 11 Top 8 matches and both get favourable matchups during Origin-affected weeks.
The main conclusion is that the interior of Iapetus behaves (or behaved during origin of ER) like a fluid.
If this was the case, then one would not expect histone modifications to change during origin activation.
The low level of K36me3 at early firing ARSs and its decrease during origin activation both support an inhibitory function of this modification in origin firing.
Furthermore, during origin of life formation there perhaps existed two kinds of amino acids: one the L-form, and the other is D-form.
Our results also revealed that origin architecture was actively modulated during origin firing.
Although the specific chromatin conformations of origins are already established in G1, origin structure is dynamic during origin activation.
In addition, we conducted parallel analyses of replication and nucleosome dynamics that revealed that chromatin structure at origins is modulated during origin activation.
Nonetheless, because the TFIIB domains are preserved across eukaryotic Orc6 orthologs, it is tempting to speculate that these folds also play an important conserved function during origin licensing.
Nonetheless, additional interactions of Orc6 with pre-RC components other than ORC subunits during origin licensing could also contribute to Orc6 incorporation into the pre-RC, explaining why the MGS mutation is not lethal in humans.
