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Each intervention has no residual effect during Off periods and is independent of the others.
This type of study design can be used only when there is no residual affect during Off periods.
In storage rooms fans must be in operation when the refrigeration machinery is running, even though during off periods a natural circulation pattern is established; this takes some time to overcome the fan action.
The primary measure of efficacy was change from baseline in mean total daily "off" time; secondary endpoints included changes from baseline in the UPDRS-ADL subscale during "off" periods, changes in UPDRS-motor subscale during "on" times, and the investigators' clinical global impression (CGI-I) of patient improvement.
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Protests began on September 19, as students demonstrated at high schools throughout one of Colorado's largest school districts — some walking out of classes during school hours while others organized with school officials to demonstrate during off-periods.
Makita et al described the RCC patient who displayed overt hypothyroidism with an atrophic thyroid during on-periods in the sunitinib treatment cycles and who showed a recovery of thyroid size during off-periods (Makita et al, 2010).
Anxiety as well as depression also tend to be more frequent during off-periods and often getting better when the dopaminergic treatment is optimized thus having less pronounced and less frequent off-periods.
The long, phase-discontinuous condition (LongDis) (Fig. 1B.3) was identical to LongCo, except that phase-continuity was disrupted across single tACS-epochs by introducing a phase shift of 0°, 90°, 180°, or 270° to the virtual sine wave during off-periods (approximately equal probability) with respect to the previous on-period, thus initiating tACS at a different phase angle.
The UPDRS motor scores during off-period and the percentage of off time improved significantly using tolcapone in a small study of 40 patients (Shan et al 2001).
Subjects viewed a flickering radial checkerboard in a block design experiment, alternating between eyes open or closed during the off periods.
This puts them out into the halls during their off periods and between periods.
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