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Blindness is guaranteed during linkage and validation of cases.
We removed an additional 77 markers during linkage map reconstruction because they disturbed marker order stability and/or showed genotype combinations that could only be explained by two unlikely simultaneous recombination events in immediate spatial proximity or by mutation (Table S2).
Finally, to explore the chromosomal regions we identified during linkage analysis (6p25.1, 12q22, 9q34 and 20p11q11) but also the 5q31q33 and 10p15 regions, which have been described as involved in the control of parasitemia and malaria fever episodes respectively [23], [29], we performed a linkage and association study using family based association tests (FBAT) software.
On the basis of these predicted relationships, inbreeding loops were added within each pedigree to correct [35], [36] for the possibility of type I errors during linkage analyses due to increased allele IBD sharing in the families with over-related parents.
Only clusters judged valid were permitted during linkage mapping.
BAC FISH was also indispensable during linkage mapping.
Similar(38)
We further excluded 2136 patients who died during the hospitalisation for alcoholism and 733 patients with inconsistencies uncovered during record linkage.
Acetaldehyde forms during ether linkage conversion with the help of sulfate-reducing bacteria.
Prototype blocks have been realized using electro-permanent magnets which show a good motion speed while saving power consumption during the linkage.
We performed a sensitivity analysis measuring impact of error in matching cases during record linkage.
Using the blocking strategy outlined, approximately 142 billion comparisons were performed during the linkage process.
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