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In rat lungs perfused with high-glucose Kreb's solution during injurious ventilation there was significantly greater injury than in lungs perfused with normal glucose Kreb's solution (28.0% vs 10.1%, P < 0.01).
DAMPs are present in the alveolar compartment during (injurious) MV indicating the potential significance of the DAMP/receptor axis in VILI [7].
PI was added to the perfusate during injurious ventilation.
In previous experimental studies, we described a fall in renal blood flow during injurious MV of normal lungs [ 10], and benefits of poly(ADP-ribose) polymerase (PARP) inhibitor given as pre-treatment on renal function and tissue integrity in lipopolysaccharide (LPS -induced LPS -inducedwith superimposed MV [ 5], but their relungon remainjuryclear.
In the present study we used a novel model of non-lobar atelectasis through non-selective bronchial blocking in rats, and investigated its effects on the atelectatic area as well as on the surrounding healthy lung tissue during injurious mechanical ventilation.
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Pro-thrombotic and anti-fibrinolytic responses, which are helpful during focal injury, may be injurious in the setting of systemic endothelial injury and are manifested by thrombocytopenia, systemic thrombosis, and multiple organ failure.
Challenges in accurate, in vivo quantification of multi-planar knee kinematics and relevant timing sequence during high-risk injurious tasks pose challenges in understanding the relative contributions of joint loads in non-contact injury mechanisms.
Although essential for tissue survival, oxygen can be injurious during reperfusion.
It should be noted that a substantial number, almost one third, of those with no, a single, or recurrent falls during the initial monitoring year also experienced injurious falls during the long-term follow-up which were severe enough to seek care at the hospital ED.
Violent or injurious behaviors during sleep, sleep paralysis, sleep talking, and hypnagogic and hypnopompic hallucinations were more frequently reported in respondents with PTSD.
Ki was lower during protective (vs. injurious) ventilation, especially in dependent lung regions (0.0075 ± 0.0043/min vs. 0.0157 ± 0.0072/min; P < 0.01).
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