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Two patients were not treated due to disease progression during dosimetry.
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Background renal pelvis signal, indicating homogeneous distribution throughout the kidney, was observed in 40% (6/15) of mice imaged, while the mouse imaged during the dosimetry study (Figure 2c, arrow) exhibited the highest levels.
Two patients with transformed disease did not receive the administration of therapeutic I-tositumomab activity because of rapid disease progression during the dosimetry phase.
In routine practice, however, this formula is difficult to use for decision making during the dosimetry, since it uses volumes that often can only be calculated when the dosimetry is finished.
We have implemented specific design features to optimise the performance of the dosimeter for specific in-vivo dosimetry during brachytherapy.
The aim of the project was to design and test both metrologically and in clinical conditions OSL optical fiber sensors dedicated to in vivo dosimetry during external beam radiation therapy treatment with high-energy electrons.
The system is free from magnetic and electrical interference, and is designed for use in several forms of radiotherapy, including in vitro brachytherapy source calibration, and in vivo dosimetry during patient treatment.
This is a key advantage, in the light of recent studies showing the high impact of segmentation inaccuracies on the dosimetry during radiotherapy treatment in the case of heterogeneous or low intensity lesions [4].
This time interval represented the earliest time period during which complete dosimetry was initially captured at our hospital prior to the multitude of iterative and variable changes introduced through quality improvement in imaging to reduce radiation exposure.
All patients had in vivo TLD dosimetry during the initial fraction of TBI.
Considering this short time scale, it is feasible to perform personalised MRI-based dosimetry during the actual RE procedure.
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