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Hypertrophy an increase in the size of the cells in a tissue or an organ occurs in heart muscle during diseases involving the heart valves, in certain pneumonias, and in some diseases of the endocrine glands.
This gradient may be disturbed during diseases of the joint, for example in rheumatoid arthritis when synovial fluid pO2falls.
There is evidence that circadian rhythm of activity is disrupted under chronic stress in animals and humans, and it may also be less marked during diseases.
Altered BBB transport of drugs into the CNS during diseases may be the result of changes in both specific transport and non-specific transport pathways.
IL-10 favors the balance between pathology and protection during diseases that course with inflammation.
However, little is known about the influence of pathological conditions on MEC function; e.g., during diseases associated with elevated intracranial pressure, hypoxia or increased oxidative stress.
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Abnormal proteolysis is often observed during disease progression.
We, therefore, have used this model to define temporal changes in peptidomic profiles during disease progression.
Tropical countries suffer proportionally greater losses during disease outbreaks (Robar et al. 2010).
There are three stages during disease progression, i.e., a normal state, a pre-disease state and a disease state.
Surprisingly, in mice, soluble huntingtin levels decrease during disease progression, inversely correlating with brain aggregate load.
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