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The highly dynamic nature of the ECM causes several alterations during diseased conditions that result in the loss of cells specified for the desired function (Cattell et al. 1996).
Concerning AD, β-amyloid (Aβ) plaques are characteristic of this condition and their presence during diseased states has been well documented [37].
It may be the case that miRNA expression is maintained in healthy but senescent tissue and only during diseased states do perturbations in normal expression take place.
The overall findings of our study also provide a solid platform to further investigate the additional epigenetic interplay at the subtelomeric loci during diseased state.
While the exact required mechanical stiffness to match native heart tissue remains unknown due to the vast changes in heart stiffness during diseased stages, the mechanical strength of PA-RGDS can be tuned for the application as previously reported.
This study thus represents an important step towards understanding the mode of action of OPP during healthy states, before further studies are carried out to identify the molecular mechanisms involved during diseased states.
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The reduction in the numbers of pDCs has been reported [ 52] and may reflect recruitment from the peripheral blood to diseased tissues during disease episodes [ 53, 54].
These findings suggested that the autonomic dysfunction is not simply an accompanying phenomenon during the diseased stage but a biological trait marker in patients with RCVS.
This study also sets the scene for identifying the molecular modes of action involved in conferring the positive biological effects of OPP during various diseased states.
Molecular profiling of samples representing healthy or diseased states, pre- and postintervention, or time series during disease progression is important research topic in biomedicine.
Plotted in Figure 4 are the proportions of individuals ever diseased during
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CEO of Professional Science Editing for Scientists @ prosciediting.com