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In order to investigate the consequences of LC and pDC absence during defined phases of psoriatic inflammation, we employed DKO* mice bred to either Langerin-DTR (LanDTR) mice (Kissenpfennig et al, 2005), or to BDCA2-DTR mice (Swiecki et al, 2010), in which LCs or pDCs could be inducibly depleted by injection of DT, respectively.
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To quantify the effects of IGF-1 defineddefined growth phases, we developed an inducible liver IGF-1 deficient mouse model (iLID) that allows us to deplete circulating IGF-1 at specific stages of mouse development.
Until now, KEGG pathways cover TF networks only to a limited extent, and further refinement of this approach (Rahnenfuhrer and Leist 2015) may lead to the identification of subnetworks as regulatory principles explaining waves of transcript changes and windows of sensitivity to toxicants during defined developmental phases (Kuegler et al. 2010; Zimmer et al. 2011).
Because phase change is a composite character, efforts to define phase state based on a single trait that changes during phase transition are illusory [ 49].
Defining Phase 2 could take a while.
A total of 63.3% of all deaths occurred during the defined late phases II and III, which implicates a broad clinical significance.
In this study, trace element partitioning among operationally defined solid phases was assessed during winter and spring only.
The World Health Organization (WHO) has defined several phases before and during an influenza pandemic (Table 1) [ 3].
Fluid release and insect colonization during active and advanced decay, defined as phase two, stimulated soil microbial communities, particularly those able to degrade phospholipids and nucleic acids.
The choice latency was defined during both phases as the time from when the animal passed through the entrance door to when it passed through the choice door.
Characteristically the disease outcome is defined during this phase, when patients can either recover rapidly or progress to a severe life-threatening stage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com