The results of simulation also indicate that during circulation, a higher equivalent circulating density is expected as compared to the case of constant fluid density.
Casing pressure is readily available during circulation.
Excessive high mud pressure may lead to tensile failure and loss of fluid during circulation.
A simulator was developed to calculate the wellbore temperature and pressure during circulation and static conditions.
The cleavable PEG could increase the stability and circulation time of liposomes during circulation.
The compressive strength decreased during circulation and with the circulation time.
In addition, aggregated proteins are likely to function as immunogenic substances, provoking undesired immune response during circulation in bloodstream.
To further enhance stability during circulation, methyl groups are often installed next to the disulfide bond (Saito et al., 2003).
High DAR can increase not only potency but also the risk of aggregation, clearance rate, and premature release of the toxic payload during circulation.
Both unsuccessful ADCs suffered from toxicities and low tolerability, which seems to be attributed to lability of the hydrazone linker during circulation.
Delayed antigen release from NPs may reduce loss of antigen during circulation and increase bioavailability of antigen to DCs, thereby enhancing immune response.
