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A NATO military spokesman in Kabul emphasized that commanders were not second-guessing troops, but urging them to practice "courageous restraint" and recognize that "you are more likely to be hurting someone who is confused rather than dangerous if you open fire" during an escalation of force episode.
The Kunduz assault marks a troubling development in the insurgency, although Afghan forces have managed to drive the Taliban back from most of the territory they have gained this year during an escalation in violence.
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Johnson declined to act, stating that an escalation during the Christmas period would be inappropriate, as it would damage public morale.
The open-label study comprised a Baseline Phase, an Escalation Phase during which lamotrigine was titrated to a target dose, an 8-week Maintenance Phase during which doses of lamotrigine and concomitant antiepileptic drugs were maintained, and a 12-week Optimization Phase during which doses of lamotrigine and other antiepileptic drugs could be adjusted.
For example, a level of 20 mg/kg/day during initial exposure results in an escalation of subsequent BPs, whereas an intake of 60 or even 100 mg/kg/day results in stable responding on a PR schedule [ 39].
Animal miRNAs appear to have expanded in conjunction with an escalation in complexity during early bilaterian evolution.
Naim Khatib said his children were scared by the fighting, having lost their home during a previous escalation in violence.
Patients (n=63) were transitioned from valproate to lamotrigine during an 8-week escalation phase followed by 24 weeks of lamotrigine monotherapy.
In cases where FCAS was not completely controlled after the follow-up treatment, the patients received dosage increases of 160 mg/week to 320 mg/week during an intrapatient dosage escalation phase.
In the clinical setting, the administration of small doses of a second opioid in patients with an unfavourable response during escalation with the prior opioid has been found effective in a preliminary experience, not yet published by our group.
Availability of a quantitative prediction model during dose escalation that is updated with emerging clinical data from early dose panels may give increased confidence in predicting pharmacology and safety.
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