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Even the idea that the sample of patients was in some way biased by its age and sex composition has been ruled out.Cold comfortRegardless of exactly what happened during ACCORD, the result suggests the sceptics were right to think that attacking the symptoms of diabetes is not enough.
For the DTSQ measure, during ACCORD vanguard, which enrolled 1,184 patients, item 8 (recommend treatment to others) was not assessed in either treatment group.
Height loss of >2 cm during ACCORD was experienced by 678 (19.5%) participants in the intensive and 686 (19.6%) participants in the standard glycemia group (odds ratio [OR] 0.99 [95% CI 0.88 1.11]).
Aside from concomitant TZD treatment, low HDL-C at baseline, a history of coronary heart disease, and the baseline prevalence of lower alcohol intake were associated with low HDL-C levels during ACCORD follow-up (data not shown).
In all, the proportion of lipid trial participants who ever had an extremely low HDL-C during ACCORD was more than two times greater among those randomized to fenofibrate than among those randomized to placebo (10.1 vs. 4.9%) (Table 1).
The trend for increased hypoglycemia risk among older participants was identified early during ACCORD follow-up in those ≥80 years old at randomization, where early monitoring of hypoglycemia rates by the external data and safety monitoring board (DSMB) identified elevated rates of hypoglycemia in participants who were ≥80 years old at randomization.
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