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Demonstration of increased SCIT efficacy in symptom control has also been shown for longer durations of maintenance therapy (up to 3 years), although the increased efficacy evidence from this study is weak versus SCIT therapy duration of 1 year.
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Variability in practices was observed in several aspects of patient care, including (1) indications for CMV-negative blood products, (2) surveillance tests used to detect CMV infection, (3) duration of surveillance testing, (4) duration of maintenance treatment after preemptive therapy was initiated, and (5) treatment of CMV disease.
The duration of maintenance is also uncertain.
Maintenance therapy can last for years, and the optimal duration of maintenance therapy is unknown.
The median duration of maintenance with weekly FL was 38 weeks (8 91 weeks).
The median duration of maintenance treatment was 10 weeks (range, 2 17).
In addition, the ideal duration of maintenance therapy should also be investigated in the future.
In case of high relapse rates after discontinuation, guidelines should be adapted regarding the duration of maintenance treatment.
2,5-A synthetase activity was compared with response to intensive therapy and with duration of maintenance therapy.
The overall median duration of maintenance therapy was 8 months (range, 0.5 24 months), and the overall median maintenance dose was 200 mg/day (range, 200 1800 mg/day).
Even though medical literature highlights the pivotal significance of tapering the immunosuppressive treatment, there are few guidelines on the duration of maintenance therapy or the prerequisites of discontinuation.
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