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The median durations of grade 3 and grade 4 neutropenia were one day and two days, respectively.
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The median duration of grade 4 neutropenia was 6 days.
The median duration of grade 3 and grade 4 neutropenia was one day.
The median duration of grade 3/4 peripheral neuropathy was 2.3 months (range 0.2 2.5).
Duration of grade 1, 2, 3, 4 leukopenia throughout chemotherapy cycles 1, 2, 3. Duration of grade 1, 2, 3, 4 neutropenia and febrile neutropenia throughout chemotherapy cycles 1, 2, 3.
In all age groups, the median duration of Grade 3-solicited general symptoms ranged between 1 day and 2 days.
At all higher dose levels the incidence of grade 3 4 neutropenia was ifosfamide dose dependent, but the duration of grade 4 neutropenia was less than 5 days.
Although in cohort 2 no neutropenic fever was encountered, neither the frequency nor the duration of grade 4 neutropenia and thrombocytopenia were reduced.
Two patients were excluded from the DLT analysis because G-CSF was administered before the duration of grade 4 neutropenia had been determined (protocol violation).
The median time to first occurrence of peripheral neuropathy (of any grade) was 4 months (range 0.3 30.9), and the duration of grade 3/4 peripheral neuropathy was a median of 2.3 months (range 0.2 2.5) with proper dose modification.
The median duration of grade 3 4 cytolysis was 6 and 8 days, respectively, and median time to recovery to grade 1 (2.5 × ULN) was 15 and 16 days for ASAT and ALAT, respectively.
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