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In vivo prion protein gene-small interfering ribonucleic acid treatment effects were of limited duration, restricted to secondary lymphoid organs and resulted in a 70% reduction of cellular prion protein expression in leukocytes.
However, in a multivariable model for cough duration restricted to patients in the former group, HIV-infection [estimate = −14.85 (−27.87, −1.838); p = 0.0267], and heavy alcohol usage [estimate = 85.14 (44.77, 125.5); p <0.0001] were the only significant associates of cough duration (Additional file 1: Table S6).
More specifically, licensing RCTs may often be too short in duration, restricted to highly defined patient groups, and use comparator therapies that are not routinely used in national health care practice (Section 3.3.3 GMTA).
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The cursor duration is restricted by the display capabilities of computer hardware.
Due to the limited availability of telescope time for daily monitoring efforts, the INT session duration is restricted to 1 h.
RV/IVC wall invasion was significantly correlated with OS if the follow-up duration was restricted to within 1 or 2 years.
The surgical category was very strongly correlated with OS in any datasets in which the follow-up duration was restricted to within 1, 2, or 3 years.
The SIRs did not vary by age at TGCT diagnosis (Pheterogeneity=0.19) or follow-up duration (Ptrend=0.13, restricted to the first 25 years of follow-up).
The statistical models employed by Gene Mark and AUGUSTUS involve implementations or approximations of an HMM with duration (HMMD), where state durations are not restricted to be geometric, as in the standard HMM modeling (further details are given in the background section to follow).
Examination length was restricted to reduce the duration of the anaesthesia therefore not all measurements were taken on all conceptuus.
Only three studies published results according to duration of smoking, and of these only one (Green et al, 2003) published results for duration of smoking restricted to current smokers.
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