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Parameters were simultaneously fitted to action potential (AP) morphology, action potential duration (APD) restitution and conduction velocity (CV) restitution curves in these patients.
These wavelets may arise due to dynamical instabilities, which are associated with action potential (AP) duration (APD) restitution properties (the so-called restitution hypothesis) (34, 12, 36, 54, 40, 9, 37) and intracellular calcium dynamics (55).
Cell models, for atrial wall, crista terminalis, appendage, Bachmann's bundle and pectinate myocytes are characterised by action potentials, ionic currents and action potential duration (APD) restitution.
For example, since the repolarisation current contains no gating variables, it does not exhibit rate dependence of repolarisation and in particular cannot reproduce action potential duration (APD) restitution.
Furthermore, the functional consequences of differential expression of ERG1 isoforms were explored as a potential mechanism underlying native heterogeneity of action potential duration (APD) and restitution.
Furthermore, we describe how differential expression of hERG1a and hERG1b may in turn modulate both action potential duration (APD) and restitution properties.
We used Langendorff whole heart preparations to examine ventricular effective refractory periods (VERPs), response latencies, electrogram durations (EGDs), APDs, alternans, and restitution curves, to show increased arrhythmogenic potential specifically in the RVOT of murine Scn5a+/− hearts for the first time.
We present a minimal ventricular (MV) human model that is designed to reproduce important tissue-level characteristics of epicardial, endocardial and midmyocardial cells, including action potential (AP) amplitudes and morphologies, upstroke velocities, steady-state action potential duration (APD) and conduction velocity (CV) restitution curves, minimum APD, and minimum diastolic interval.
Electrical restitution, relating action potential duration (APD) to diastolic interval (DI), was believed to determine the stability of heart rhythm.
The authors also examined model response to rate dependence and restitution of cardiac AP duration (APD).
Restitution, the characteristic shortening of action potential duration (APD) with increased heart rate, has been studied extensively because of its purported link to the onset of fibrillation.
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