In the winter of 1950-1951, with Stephenson's six months' leave with Western about to expire, he was in and out of New York pressing for a written contract of definite duration and of substantial length.
Although it remains possible that anti-B-cell therapy is not sufficient to suppress lupus activity, a number of other confounding variables of SLE trial design may have substantially contributed (too short trial duration, allowance of substantial glucocorticoid usage, heterogeneity of the patient population, etc).
Despite matching for baseline best corrected visual acuity (BCVA) and duration of disease, substantial heterogeneity existed between anti-VEGF RCTs.
Risk factors that have been implicated in the development of ION in spine surgery include male sex, obesity, prolonged intraoperative hypotension, long duration of surgery, substantial intraoperative blood loss, and the excessive use of intravenous replacement fluids, or anemia.
However, given a background of reports of recent safety problems [ 4– 6] and questions about optimal duration of use, substantial declines in prescriptions and sales of oral bisphosphonates (since 2007 2008) and intravenous bisphosphonates (since 2010) for osteoporosis treatment have been observed [ 3].
Although dexamethasone has documented efficacy for reducing the duration of ACS, the substantial risk of readmission for pain should limit its use.
When such adjacent instances of gesturing (<1 min separation) were combined (henceforth termed 'lumped bouts'), the duration of gesturing was substantial, averaging 8.8±1.5 min (range: 2 s – 36.2 min, N = 33; see Table S1 for data on each gesturer separately).
Mean HbA1c levels were also higher with longer duration of obesity, with substantial reductions after adjustment, but individuals with childhood obesity only did not have higher levels.
Here we report that ever having breastfed and the total duration of breastfeeding conferred substantial reductions in breast cancer risk among BRCA1, but not BRCA2 mutation carriers.
A closer look however, reveals many drawbacks e.g. ethical considerations, duration of RCT's, substantial resources and funding, and difficulty in blinding, just to highlight a few [ 14].
