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However, under conditions in which the cytokinesis machinery is partially compromised, clp1Δ cells display a lethal cytokinesis phenotype due to their inability to prolong the duration of SIN signaling [2], [3].
Thus, taking all data together, these results strongly suggest that Clp1p functions to extend the duration of SIN signaling upon cytokinetic perturbations, thereby providing an improved opportunity to properly constrict the ring.
This parallels the function of Clp1p in the sense that Clp1p is not required to activate the SIN (clp1Δ mutants are fully capable of constricting rings and forming septa under normal growth conditions), but is important in extending the duration of SIN signaling (as needed) in the presence of damage to the cell division machinery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com