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Fluctuation produced due to regular pumping have a smooth top since in general the duration of pumping of a well remains comparatively smaller than non-pumping.
In areas of Albuquerque where hydraulic gradients are upward during the winter, increasing the frequency and duration of pumping during the winter could minimize the quantity of high-arsenic flow through the wellbore at that time and, therefore, reduce the winter concentrations of arsenic in water produced by the well.
In areas where hydraulic gradients are downward throughout the year, reducing the frequency and duration of pumping during the summer could maximize the quantity of low-arsenic flow through the wellbore at that time and, therefore, reduce the summer concentrations of arsenic in water produced by the well.
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Also, the duration of pump surgery can be variable and the inflammatory response varies with the time spent on pump.
Risk factors were: previous use of statin (P = 0.002), intraoperative hemodynamic instability (P = 0.045), longer duration of surgery (P < 0.001), and longer duration of pump (P < 0.0001).
Associated factors with renal dysfunction were age (P = 0.045), longer duration of pump (P = 0.01) and low initial intraoperative central venous saturation (P = 0.001).
One or more pump suspensions occurred on 719 (76%) of the 942 intervention nights, with a median total duration of pump suspension of 71 (interquartile range [IQR] 29 115) minutes (Supplementary Table 4).
Patients had a median age of 41.5 years (interquartile range [IQR] 17.0), HbA1c level of 7.6% (1.2), BMI of 25.0 kg/m (4.9), duration of diabetes of 19.8 years (19.2), and duration of pump use of 3.6 years (6.1).
Twenty-four participants were commenced on the system ([means ± SD] aged 17.4 ± 9.3 years, duration of diabetes 8.7 ± 6.4 years, and duration of pump therapy 3.8 ± 3.0 years), with a median duration of use of 89 days (range 9 211).
Factors associated with cardiac dysfunction were previous low ejection fraction (P = 0.035), surgery with pump (P = 0.001), longer duration of pump (P = 0.003), low initial intra-operative central venous saturation (P = 0.001) and high level of initial gapCO2 (P = 0.02).
Median age was 14.8 years (range 12.6 24), duration of diabetes was 6.9 years (range 3.8 21.5), duration of pump therapy was 3.8 years (range 2.6 10.8), and BMI was 21 kg/m (range 18 30).
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