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For relevant patients, the duration of NP and survival were measured from the first administration of the study drug.
Patients were divided in three cohorts depending on the percentage of the final MTD of the drug received and we studied the NPR, duration of NP, and response.
The results of patients with no progression at 3 months are shown as a waterfall plot, in Figure 2. The median duration of NP for all patients was 17 weeks (95% CI: 13 22) (Cohort A: 23 weeks (95% CI: 10 36); Cohort B: 19 weeks (95% CI: 9 30); Cohort C: 15 weeks (95% CI: 12 18)), P=0.9.
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Similarly, Collembola (F. candida) showed more severe effects in their reproductive output with increasing ageing duration of Ag NP in spiked sewage sludge [193].
The effects of NPs on crop plants vary greatly with plant species, growth stages, growth conditions, method, dose, and duration of NPs exposure along with other factors.
With the introduction of baseline and follow up questionnaires and the inclusion of onset and duration of action of NP treatment, two important treatment attributes mentioned by patients in the interviews can be more efficiently captured.
The levels of inhibition/stimulation of the NPs varied notably also in relation to the soil type, duration of contact between NPs and the soil, and particle size (nano, bulk).
Therefore, the calculation of the total administered dose must take into account the duration between the day of NP administration and the day the animals are sacrificed.
Using the cell and NPC ROI analysis approaches, we systematically quantified the spectral changes experienced by NPs in a cellular environment as a function of NP exposure duration and dose - two important parameters in administering NPs for biomedical applications.
At days 7 and 14, the duration of stand was longer in the NP group than in the sham group (p < 0.05) (Fig. 3a).
The daily survival rate (p) of anopheles was then determined for each altitudinal site of the transect, using Davidson's formula [ 27]: (where x is the duration of the gonotrophic cycle in days, Np and Nn the numbers of parous and nulliparous females respectively in the population).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com