Dr. Zito said the challenge for researchers was to establish the need for drugs, effective doses, duration of medication, and the risks.
Medication overuse headache sub-diagnosis and duration of medication overuse.
Unfortunately, information about duration of medication overuse at inclusion was not available in the present study.
The mean duration of medication was 71.7 (SD = 34.1, range: 25 142) months.
Concerning patients with pMOH, 19 patients had a duration of medication overuse > 10 years, 13 patients up to 10 years.
Illness duration, medication status, and duration of medication withdrawal are several of the clinical factors that contribute to the heterogeneity between studies.
Limited by the number of studies and a lack of patient-level data, moderator analysis was restricted to medication status, duration of medication withdrawal, and illness duration.
There was no significant difference in duration of medication overuse between Europe and LA (P = 0.13) (Additional file 2: Table S2).
The knowledge about predictors is limited, but in some previous long-term follow-up studies the prognosis has been reported to be better, e.g., in women, migraine patients, and in those with short duration of medication overuse [13 16].
Duration of mechanical ventilation was the primary outcome; secondary outcomes were total doses and duration of medications, PICU length of stay, incidence of ventilator-associated pneumonia, and occurrence of withdrawal symptoms.
Our objective was to evaluate the impact of a nurse-driven sedation protocol in our paediatric intensive care unit (PICU) on duration of mechanical ventilation, total doses and duration of medications, PICU length of stay, incidence of ventilator-associated-pneumonia and occurrence of withdrawal.
