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Both amplitude (dose) and duration of input signals provide information that regulates cellular decisions.
A longer duration of input will not increase the fraction of activation over this value.
Together, experimental findings, simulations, and mathematical analysis demonstrate how cells integrate amplitude and duration of input signals in switch-like pathway activation.
DOI: http://dx.doi.org/10.7554/eLife.08931.009 Cellular environments like infected tissue encode information in both amplitude and duration of input signals (Gottschalk et al., 2012; Fu et al., 2014).
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Key design features are identified that reveal FPE efficiency, operating frequency, and output power are dependent on piston mass, external load, input heat-rate, and duration of heat input.
In contrast, dominance durations of the input receiving fixed input strength and input strength to the variable input are correlated negatively for all input strengths (double WTA: r(9) < −0.96, P < 1.82 × 10−5)); experiment: r(4) < −0.89, P < 0.014)).
This is not surprising: In the left-most panel of Fig. 12, in the range when M Δ is an increasing function of Δ, the duration of the input spike volley, M Δ Δ, is much greater than 3, the decay time constant of the excitatory synaptic input pulses.
Figure 12 Classification rate as a function of the time duration of the input segment.
Figure 7 Classification rate as a function of the duration of the input signal.
Thus the duration of the input pulse I ε is on the order of ε (time measured in ms).
Figure 7 records the performance of the proposed method with respect to the duration of the input signal.
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