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For course 2, the WBC, ANC, platelet nadirs, and duration of grade 4 neutropenia were 2600, 1450, 70,000, and 0 days, respectively.
For both ifosfamide/mesna/cisplatin and etoposide/cisplatin, median duration of Grade IV neutropenia was short (< or = 4 days), time to subsequent courses 21 days and dose delivered > 95% of planned dose.
The median duration of grade 4 neutropenia was 6 days.
The median duration of grade 3/4 peripheral neuropathy was 2.3 months (range 0.2 2.5).
The median duration of grade 3 and grade 4 neutropenia was one day.
Duration of grade 1, 2, 3, 4 leukopenia throughout chemotherapy cycles 1, 2, 3. Duration of grade 1, 2, 3, 4 neutropenia and febrile neutropenia throughout chemotherapy cycles 1, 2, 3.
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The median durations of grade 3 and grade 4 neutropenia were one day and two days, respectively.
Fifteen patients reported diarrhoea grade 2 and four had diarrhoea grade 3. The median duration of diarrhoea grade 3 was 6 days (range 3 8 days).
The goals of the optimisation was to identify a G-CSF schedule with minimal duration of neutropenia (grade 3), neutropenia level at the onset of the subsequent Doc administration higher than the grade 2 cutoff, and to minimise the amount of G-CSF and the number of G-CSF administrations.
In contrast children who have a brief duration of low grade fever (≥ 38.5°C) and no history of lethargy are of low risk of neurological disease, and may be provided with out-patient care and parental reassurance.
A total of 89 high-dose cycles with a median number of 3 (range, 3 4) per patient were given to the 28 patients with mediastinal primary tumours resulting in a median duration of WHO grade IV granulo- and thrombocytopenia of 6 and 4 days.
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