Previous studies have used averaged puff profiles, with smooth, periodic parabolic waveform and a fixed puff frequency, volume, and duration, to conduct machine smoking measurements of puff topography and mainstream smoke constituents.
Statistical analyses of spring flow parameters including activity periods and duration of flow were conducted.
The maximum duration of the study conducted for IL-1β was 300 days; IL-2, IL-6, IL-8 and TNF-α were 90 days; RANKL and OPG was 30 days; and CS was 35 days.
For each sample, the duration of the experiment conducted was 5 min.
A pooled analysis of safety data from seven multicenter, randomized, blinded, Phase III clinical trials (4 12 weeks' duration) of TDiclo was conducted.
A RCT to increase the duration of breastfeeding was conducted in eight public maternity hospitals in metropolitan Western Australia from 2008 2009.
To assess the possible sources of heterogeneity among the included studies, subgroup analysis based on tofacitinib doses and type of therapy (monotherapy vs combination therapy) and meta-regression with two covariates (dose and duration of therapy) were conducted.
To determine whether recall error is likely to have seriously reduced accuracy of the estimated survivor function and median duration of use, we conducted a Monte Carlo simulation to assess the degree of uncertainty in these estimates caused by recall error.
Thirty-seven percent of respondents reported that searching for specific questions related to drug information (e.g. usual dosage, duration of therapy) was conducted using both print and electronic resources (but print use greater than electronic) (Table 2).
After informed consent, face-to-face interviews of ∼60 min duration were conducted by one of the co-authors, M.T.B. (an experienced qualitative researcher), on hospital premises, adopting an open-ended approach (i.e. without using leading questions, allowing the informant to take the lead and probing revealed themes in depth).
