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Markedly elevated white blood cell count (>18,000/mm3), palpable tender mass in the right upper abdominal quadrant, duration of complaints >72 h, and marked local inflammation (gangrenous cholecystitis, pericholecystic abscess, hepatic abscess, biliary peritonitis, emphysematous cholecystitis) are considered as signs of grade II (moderate) acute cholecystitis [7].
Additional data recorded were age, sex, and duration of complaints.
Duration of complaints was reported most often (table 2).
One covariate is pre-specified as a primary effect-modifier: duration of complaints at randomization.
The average duration of complaints was 77 months (range 2-480, median 24 months).
There were large differences in the duration of complaints at baseline between studies.
The difference in duration of complaints at baseline also complicates comparison between studies.
Meanwhile a long duration of complaints is a predictor for poor outcome.
A series of demographic variables were obtained including age, gender, height, weight, and duration of complaints.
The age at symptom onset was 32.2±7.4 years and the mean duration of complaints was 44.2±38.1 months.
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Therefore each of the main analyses is accompanied with an extension to test for "duration-of-complaints" * "treatment" interaction.
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