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There was no evidence that the association between vegetarianism and diverticular disease differed according to duration of adherence to a vegetarian diet.
There was no significant association between age or duration of adherence to a vegetarian or a vegan diet and serum vitamin B12.
For example, adherence could be assumed to be random in time, periodic with a given duration of adherence and non-adherence, or stochastic based on a Markov model described in detail below.
We wish to be able to detect a statistically significant difference of minimum 8 weeks between the two intervention groups with regard to average duration of adherence to the discontinuation plan with 90% probability.
Mean serum vitamin B12 was not associated with the duration of adherence to a vegetarian or vegan diet, which may indicate that mechanisms that maintain circulating concentrations of vitamin B12 are upregulated in vegetarians and vegans.
It is possible that the median duration of adherence to treatment (2.8 years) and follow up (3.4 years) in VITATOPS was insufficient to identify or exclude any longer-term effects of therapy with B-vitamins on fracture risk.
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Longer durations of adherence states permit reversion of resistance, leading to a smaller proportion of time spent in the resistant state.
Given the uncertainty from the literature on the persistence of medication adherence, 10 years was chosen as the base-case time horizon, to correspond with a plausible duration of improved adherence.
18, 39 A further limitation could be consistency in duration of reported adherence with the gel formulation.
The SHAS questionnaire also did not adequately capture the composition of a person's past and current antiretroviral therapies, or the duration of, and adherence to, those therapies.
The objectives were to: Describe the duration of use, adherence to and persistence with tamoxifen in a geographically defined population of women.
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