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Onset > 1 year ago, probable duration lifelong".
Probable duration lifelong.
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Some pairs do separate in the first few months, but almost all pairings of over six months' duration are lifelong, ending only when a partner dies.
A potential limitation of our analysis could be the assumption of a lifelong duration of protection.
We assume the vaccine is 100% effective with lifelong duration of protection.
In addition, lifelong duration of protection was assumed in base case for cross-protection against CIN2/3 and CC lesions.
For simplicity, we assumed that the vaccine has 100% efficacy with lifelong duration of protection and that the vaccine had no effect on those already infected.
As has been performed in most published studies on vaccine cost-effectiveness (8, 13, 14, 28 ), we repeated the analysis using 100% efficacy and lifelong duration of vaccine immunity.
Accumulating evidence suggests that IBD is caused by an inappropriate response of the innate and acquired immune systems to commensal microbiota. 1 Even if IBD enters remission as a result of treatment, it often relapses, leading to its lifelong duration.
We included the costs of treating medically attended adverse reactions but not related losses of quality of life as the adverse reactions were assumed to be of short duration and without lifelong effects.
The results demonstrate that early pregnancy-induced reductions in the proportion of PR-positive cells and expression of basal epithelial Wnt targets versican and keratin 15 persist into advanced age, and thus are of lifelong duration in mice.
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