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Figure 1 illustrates the expected accrual as additional sites are added to the study and that full accrual potential is not reached until approximately 1/3 of the trial duration has passed.
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However, the median follow-up duration had passed 3 years, DFS at which point has been shown to have good correlation with 5-year OS in colon cancer (Sargent et al, 2005).
1. Wait until the desired duration of diabetes has passed and euthanize the mice by an approved method.
The reimbursement schedule follows a discontinuous discrete step function once the provider has passed a treatment duration threshold the fee is flat until a next threshold is reached.
Little legislation has passed.
An era has passed.
That time has passed.
The vogue has passed.
The storm has passed.
So time has passed?
That era has passed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com