Glucocorticoid use (dose, duration, administration) depends on the diagnosis, indications for glucocorticoid therapy, and the goal of treatment (see Table 2).
Anticoagulant protocols based on heparin are applied in a large number of experimental studies using the sheep in vivo model, however, due to short effect duration, administration every 4 hours is necessary [ 15].
For the patient, the number of drug units, the frequency and duration of administration, the convenience of administration and its invasiveness may all influence compliance with the treatment.
Approximately 220 of the 392 prescriptions did not meet the criteria for rational antibiotic prescriptions with regard to antibiotic selection (22.7%), duration of administration (72.3%), frequency of administration (3.2%), or duration and frequency of administration (1.8%).
Multivariate analysis revealed that colistin duration of administration was an independent risk factor for KPRC infection (OR (95%CI) 1.15 (1.02–1.31) per day of administration) (P = 0.025).
No significant correlations between liver enzymes and duration of administration were observed and there was no significant difference in liver enzymes during versus after intravenous administration.
There are data to suggest that the risk of complications, especially hemorrhagic complications, increases as the duration of administration increases.
See, e.g., 21 CFR § 801.109 (requiring labels to include such information as indications, effects, routes, methods, frequency and duration of administration, relevant hazards, contraindications, side effects, and precautions).
The German Commission E lists the uses, contraindications, side effects, interactions with other drugs, recommended dosages, mode and duration of administration for ephedra.
The RSV season is assumed to last five months, and this also reflects the duration of administration in both palivizumab RCTs [5, 6].
Only 2% of pastoralists followed all of the directions for dose, frequency, and duration of administration for oxytetracycline, and 1% followed all directions for penicillin.
