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"The ability of Qnexa to produce durable weight loss can be expected to contribute significantly toward ameliorating some of the consequences of obesity and weight-related comorbidities," Vivus said in its own briefing document, which was also posted on the F.D.A. Web site.
BACKGROUND: Laparoscopic gastric bypass (LGB) has proven efficacy in causing significant and durable weight loss.
Laparoscopic adjustable gastric banding (LAGB) has been proposed as a therapeutic approach to achieve durable weight loss in morbidly obese subjects [16].
In Western countries, bariatric surgery offers durable weight loss but morbidity rates are high, preventing its further application.
This is consistent with findings from 1-year pramlintide diabetes studies, which also showed durable weight loss over 1 year (12, 16, 17).
The GROS explicitly posit that information and rational (or "cognitive," in their terms) control not only fail to bring about durable weight loss but actually impair eaters' natural bodily capacities to regulate weight.
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Weight trajectories after surgery were significantly different for never-remitters, relapsers, and durable remitters, for whom greater weight loss predicted a durable remission.
The impact of BPD on type 2 diabetes is huge, with excellent effects on the glucose homeostasis and with the highest and most durable degree of excess weight loss (4).
This mostly malabsorptive approach is associated with the highest (62 75%) (16) and most durable (19) degree of excess weight loss.
Emerging data suggest that bariatric surgery results in substantial improvements in glycemia, blood pressure, and cholesterol; weight loss is durable; survival may be improved; and surgical risks are low.
Our findings show that pramlintide in conjunction with LSI induces weight loss that is durable up to 12 months.
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CEO of Professional Science Editing for Scientists @ prosciediting.com