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Herein, irRC can help us to explain why 20%to25%5% of patients with metastatic melanoma had durable survival after receiving ipilimumab, whereas RECIST or WHO criteria could not capture survival outcomes of patients as the new patterns of response rates (Wolchok et al., 2009; Hodi et al., 2010).
This short-term reduction in the recurrence risk translates into a durable survival benefit.
Although reinduction therapy with platinum compounds may again produce responses, durable survival is rare.
The ultimate goal is to achieve a durable survival benefit that allows patients to be considered "cured".
Data for immunotherapies show that although some patients attain a durable survival benefit, response rates may be lower than expected.
Recent studies have shown that perioperative chemotherapy yields a substantial pathologic response that result in durable survival time [ 24].
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How do we identify the best combinations to use, to try to raise the efficacy?" In addition, "The concentration of translational research was on moving the median survival a few months to the right [of the curve]…What ipilimumab showed is that you can do that, but you can also get a tail on the curve where you get durable survivals that last for years and decades even of those patients".
In this report we describe a novel technique of hepatic resection followed by margin ablation using IRE as a treatment for CRLM near major vascular structures, resulting in long-term and durable patient survival.
These include better collaboration between people and robots, durable technologies for survival in hostile environments, better "closed-loop" recycling systems for the re-use of resources, and improved telemedicine.
Nivolumab is a monoclonal antibody against programmed death 1 and has become a standard treatment of advanced melanoma because of its durable response and survival benefits.
However, CRs typically underpin durable 5-year survival.
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