Andtbacka, R. H. et al. Talimogene laherparepvec improves durable response rate in patients with advanced melanoma.
When gross total resection is impossible, rapamycin and everolimus should be considered, but may not offer a durable response.
Not all patients obtain a significant or durable response from ECP.
As for solutions, voluntary repatriation provides the most durable response, followed by local integration and resettlement to a third country, although this option is open to few refugees.
At the end of the day, a commitment to scientific rigor in public policy analysis is the only durable response to potential attacks on credibility.
Remarkable clinical efficacy, durable response and low toxicity of programmed death 1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockades have been observed in various malignancies.
Progression-free survival and response and durable response rates showed a highly significant difference favouring dacarbazine oblimersen and a nearly significant survival difference.
Although immunotherapy (e.g., ipilimumab, pembrolizumab and nivolumab) can achieve long-term and durable response, rate of adverse events is extremely high.
GSK2857916 was well tolerated and demonstrated a rapid, deep and durable response in heavily pre-treated patients with relapsed/refractory MM, consolidating the interim analyses conclusions that GSK2857916 is a promising treatment for these patients.
A later Phase III trial produced a "durable response" but missed the endpoint for overall survival.
Metastatic RCC (mRCC) rarely shows a complete and durable response to immuno- or radiation therapy [6].
