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As a result of recent breakthroughs in cancer immunotherapies, unprecedented and durable remission, and even cure, has been reported in some patients.
More importantly, it can provide durable remission for patients who have a suboptimal response to prior single-agent melphalan conditioning for ASCT, without requiring a reduction in the dose of melphalan.
Durable remission and the eradication of micrometastases are likely to be achieved with specialized monoclonal antibodies and therapeutic cancer vaccines that modulate the immune system to overcome immunosuppression and kill distant cancer cells.
We used whole-genome sequencing to investigate the genetic basis of a durable remission of metastatic bladder cancer in a patient treated with everolimus, a drug that inhibits the mTOR (mammalian target of rapamycin) signaling pathway.
Nearly all the children still responded to methacholine at 5 years of age, even those who were apparently in durable remission.
The time to durable remission was defined as the number of days from the first day of treatment to the first day from which platelet count did not worsen for at least 30 consecutive days.
Similar(17)
Adoptive T-cell therapy to target and kill tumor cells shows promise and induces durable remissions in selected malignancies.
Despite the promising data of novel immune checkpoint inhibitors, only a small subset of patients with UC achieves durable remissions.
Despite the recent approval of drugs such as sorafenib, sunitinib, and temsirolimus, durable remissions of metastatic disease are rare.
The emergence of systemic immunotherapies, heralded by drugs targeting immune checkpoint blockade, can provide durable remissions in a subset of patients with a favorable toxicity profile.
Clinical trials using immune checkpoint inhibitors (ICI), and adoptive transfer of genetically modified T cells have demonstrated durable remissions in subsets of cancer patients.
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