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Since other research has shown that holding a muscle in a shortened position for a long time can lead to permanent contraction, high heels could have a durable effect on aficionados' anatomy.
This phenomenon of a durable effect on complications of prior metabolic control was named "metabolic memory".
Their durable effect on glycemic control results from combined action to both augment β-cell function and enhance insulin sensitivity.
The TZDs appear to have a more durable effect on glycemic control, particularly compared with sulfonylureas (55).
Metformin increases GLP-1 secretion by intestinal L-cells (106– 108), and the combination of metformin plus DPP4i may exert a more durable effect on β-cell function.
Antagonizing IL-1β led to a clear and general anti-inflammatory response, exemplified by the potent and durable effect on hs-CRP.
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Among the three infertile mice treated with the low-dose regimen, infertility remained complete at 1 month of recovery (mating month 3), indicating a durable effect of JQ1 on spermatogenesis.
Our interpretation is that this only represents an apparent increase of incidence, probably due to the durable effect of trastuzumab on the other metastatic sites; similar data, indeed, have been also reported with the introduction of other highly effective chemotherapies, like platinum-based for ovarian cancer [ 20] and taxane-based for breast cancer [ 21].
Current evidence suggests a positive, durable effect of phentermine/topiramate ER on the cardiometabolic sequelae of obesity, including improving glycemia and blood pressure, and ameliorating obstructive sleep apnea.
The benefits of former intensive insulin treatment persisted for 13 14 years after DCCT closeout and provide evidence of a durable effect of prior intensive treatment on neuropathy.
Moreover, the benefits of former intensive insulin treatment persisted for 13‐14 years after the DCCT closeout and provide evidence of a durable effect of prior intensive treatment on both peripheral [ 12] and autonomic neuropathy [ 13].
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