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Finally, the Maraba MG1 strain had a 100-fold greater maximum tolerable dose (MTD) than WT Maraba in vivo and resulted in durable cures when systemically administered in syngeneic and xenograft models.
Here, too, HIV is aligned with the broader health response, which seeks to expand access to effective vaccines and durable cures to a range of other diseases.
We hypothesize that new therapies are needed that target cancer stem cell-like tumour initiating cells (TICs) to provide durable cures for NB.
Treatment during a time of lower transmission may be more promising, yielding durable cures because of the low risk of reinfection at such time, and furthermore, lowering the number of infectious individuals at the beginning of the next peak season.
While many tumours regress after treatments that target proliferating tumour cells, durable cures may be rare if therapeutic agents do not also eliminate TICs (Graham et al, 2002; Konig et al, 2008).
Therapeutic outcomes for younger patients with AML have improved over the past 30 years, possibly due to improvements in supportive care, for example, the use of antibiotics; 2 however, durable cures occur in the minority of patients with standard therapy.
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However, virtually all tumors become resistant and recur as castration-resistant PCa, which has no durable cure.
Blood and marrow transplant (BMT) offers children with life-threatening illness, and their families, hope of durable cure when no other curative treatment is available [ 1].
This is consistent with durable cure rates particularly in SUI surgery (there is still some question regarding efficacy of transvaginal POP repair, compared with native tissue repair).
Most patients who elect treatment of their prostate cancer expect to achieve all three components of an ideal outcome: long-term durable cure of their cancer, maintenance or improvement of urinary function, and preservation of erectile function.
Despite recent advances in the treatment for metastatic prostatic adenocarcinoma, clinical management of this tumor type remains a major challenge, and there is as of yet no durable cure for advanced disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com