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The variable speed and durability of response to antidepressant medications in geriatric depression is a significant clinical problem.
O'Connell and Velanovich reported on the durability of response to RFA with and without fundoplication.
The durability of response to PLX4032 is still under evaluation (BRIM3 trial; ClinicalTrials.gov number NCT01006980).
It is therefore uncertain if the persisting OCB have any clinical significance with regards to the durability of response to treatment.
Whether β-cell mass is the major determinant of insulin response is actually unknown, and there is certainly no evidence that durability of response to a given treatment will be dependent on its effect on β-cell mass or that treatment of pre-diabetes should be focused primarily on the β-cell.
The retention rate of patients receiving abatacept treatment was high, with 89% completing the 1-year double-blind portion of the AIM trial, 5 and 90% of the patients entering the long-term extension completing year 2, suggesting the tolerability and durability of response to abatacept.
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Future analyses will determine the durability of response at 24 months, including proportion of dropouts and X-rays, and gene analyses that may be important for ongoing responsiveness.
Adherence to ART is the primary factor determining the degree and durability of optimal response to treatment, including achieving non-detectable levels of plasma HIV RNA.
The durability of virologic response to APV600/RTV was also suggested in an earlier study by Katlama et al [ 21].
To test durability of the response to medication, primary and secondary outcomes' measurements were repeated 8 weeks after medication period (the 12-week follow-up visit).
Long-term durability of the response to liraglutide was demonstrated in the LEAD-3 trial, which compared liraglutide (1.2 or 1.8 mg) with 8 mg glimepiride daily during 52 weeks of treatment.
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