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Both TDD and TDDCI alleles contain similar duplication structures and should exhibit similar phenotypes.
This suggests that Bbp1 and possibly other pore membrane components of the SPB may localize to early SPB duplication structures.
Because cells released from the CDC20 arrest in a highly synchronized manner, we know we are examining the earliest duplication structures and comparing equivalent intermediates.
While we agree that the distance between spindle pole bodies is a useful method to determine the position the cell cycle, our study is the first to examine early SPB duplication structures using fluorescence microscopy, so what to use as a reference point to stage this period of pole duplication was unknown.
This unique duplication structure suggests the two copies of the CSB2 and CSB3 may have arisen through occasional tandem duplication and subsequent concerted evolution.
Its complex rearrangement and duplication structure predispose it to non-allelic homologous recombinations that cause several micro-deletion disorders [5], [6].
However, many of the observed triplications have a complex 'duplication-inverted triplication-duplication' structure, which requires only two breakpoint junctions.
We found that the Illumina Synthetic Long Reads assembly failed in the Mst77Y region, most likely because of its tandem duplication structure.
He then announced the exciting discovery of a new, as yet unnamed CNV mutation process, which produces a nested duplication-triplication-duplication structure.
This implies that further NAHR occurred within these CNVs may create different breaking points, leading to a complex duplication-within-duplication structure.
However, the duplication structure of the H2-Q region in C57BL/6 appears to be different to the mouse strain 129/SvJ [ 30].
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