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Empirical estimates of locus-specific or genome-wide spontaneous rates of gene duplication range from 10−3 to 10−7 per gene per generation [ 7, 8].
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Further analyses show that different lectin families exhibit significant difference in their expression divergence after tandem duplication, ranging from 40% for the Jacalin family to 100% for the Chitin_bind_1, Gal_binding and Phloem families.
These apparently pathogenic deletions and duplications range in size from < 100 Kb to 15 Mb.
Duplications range from 4 to 12 Mb and may occur either through generation of a supernumerary isodicentric chromosome 15 [idic(15)] or as an interstitial duplication.
Whereas the majority of subjects (22 of 35) harbor the homologous recombination reciprocal product of the common SMS microdeletion (∼3.7 Mb), 13 subjects (∼37%) have nonrecurrent duplications ranging in size from 1.3 to 15.2 Mb.
After CMA revealed the abnormalities of deletions and/or duplications ranging from 0.5 Mb to over than 10 Mb, a high resolution (at average 650 banding) retrospective karyotype was applied (Tables S1 and S2).
The duplications ranged in size from 362 kb to 11.1 Mb; one was less than 1 Mb.
Further analysis showed that the sizes of duplications ranged from 1.1 to 120 kb (data not shown).
The reported Xq28 duplications vary in size and location, however the majority are intrachromosomal duplications ranging from 0.3 to 2.3 Mb.
We simulated 311 deletions and duplications ranging from 20 bp to 10 kb in the case sample and no CNP in the control sample.
Based on the oaCGH arrays, the average population wide copy-number of the 24 duplications ranged from 1.19 to 2.19 copies per haploid genome (Table 1).
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