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After five rounds of duplication, cells contain approximately 50 100 plasmids (Hyman et al., 1982).
Given that the CNVs under consideration span many genes, both Reviewers 1 and 2 suggested targeted complementation experiments in the deletion and/or duplication cells via recombinant expression and/or siRNA-based methods, respectively.
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This protein functions in various cellular processes, such as ribosome biogenesis, centrosome duplication, cell cycle progression, apoptosis and cell differentiation [ 24].
Both compounds inhibit JAK-signal transducer and activator of transcription (STAT) signaling in AML cells with JAK2V617F mutations, but also diminish FLT3 signaling, particularly in FLT3-ITD (internal tandem duplication) cell lines.
The former is a complex network of biochemical phenomena that controls the duplication of cells.
There were no apparent differences in the rate of duplication of cells derived from the three donors.
Megakaryocyte maturation involves nuclear duplication without cell division, resulting in very large cells.
What has become clear from the growing list of BIPs is that BRCA1 is probably involved in multiple biologic programs of cellular behavior, including transcription, cell-cycle regulation, DNA damage repair, centrosome duplication, and cell growth and apoptosis.
The ciliary basal bodies organize the cortical cytoskeleton into a mosaic of cortical units and relay cellular polarities and cell shape through the geometry and timing of their duplication during cell division.
This is an important distinction that needs to be resolved as it helps to form whether the signal is controlling multiple aspects of cell cycle coordination, or just one (i.e. chromosome duplication and/or cell growth and cytokinesis).
The effects of TbLRRP1-RNAi on organelle duplication and cell division were then evaluated for basal bodies, flagellum, Golgi, FPC and FAZ in the 1K2N cells where cell division defects were first observed.
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