Sentence examples for duplication age from inspiring English sources

This random null model compensates for the different number of duplicated TFs in the different duplication age groups, and in particular among WGD versus non-WGD duplicates.

Divergence between duplicated genes often increases with duplication age [ 24, 26, 27].

We then estimated the duplication age between all SSD duplicated KO genes and their closest paralogs and found that the age distribution of SSD duplicates still differs significantly between the genome set and SSD KO set (P < 1 e − 16, χ test).

According to the aforementioned definition of gene duplication age, the age of a protein-coding duplicated gene (PDG) represents that of the ancestral species in which the duplication event that led to the generation of the extant gene was detected.

Our results suggest that duplication age and genetic buffering determine the essentiality of mouse duplicates.

After calculating the mean d N / d S ratio for each age bin of mouse duplicates, we unexpectedly found that sequence conservation is actually positively correlated with the duplication age (t), P < 10−10).

A possible reason for the difference between mouse and A. thaliana duplicate genes is differences in duplication ages because genes with functional compensation tend to be more recently duplicated (Fig. 1).

As shown in Figure 2, in all cases we observed that P E increases from a low value in young duplicates with the increasing of duplication ages; this P E -age (t) correlation is statistically significant (P < 10−4, χ-test).

The results indicate a duplication age-dependent relationship of alternative splicing and an evolutionary constraint among duplicates.

The duplication ages of all the GPCRs in our dataset was summarized in Additional file 1.

We further examined the expression profiles of human GPCRs and the "downstream genes" with respect to their duplication ages.