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In contrast to stress, we found that signaling categories are consistently enriched for retained duplicates over time.
The average number of domain occurrences per domain type increased in older domains, probably reflecting the accumulation of gene duplicates over time.
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However, as a single exon gene, it was easily duplicated over time and modern day mammals have a wide range of copies of type-I interferons, perhaps to increase overall expression levels throughout many cell types in the body.
Ballmers right on the tech side: Facebook's backend could be duplicated over time, so can Facebook last over the longer term and not be replaced by a new site/ fad?
Of course, gene duplication on its own does not create much novelty, but these duplicates diverge over time, with respect to both their regulation and their sequences.
"People change over time.
It is possible that contextual increases in the frequency of duplicate testing over time may have masked true reductions in duplicate imaging due to PACS, as may have been the case for increases in duplicate CT imaging that we observed after PACS.
The genomic localization of multiple MaSp1 loci in Latrodectus is consistent with the persistence of tandem duplicates over evolutionary time.
This provided us with greater temporal resolution in mammals than in Drosophila, and allowed us to more closely examine the functional diversification of mammalian duplicates over evolutionary time.
This strongly implies that not only are multiple interactions per gene in networks subject to subfunctionalization but that dosage balance can also play an intricate role in the retention of duplicates over long time periods.
This was commonly observed in the previous analyses (e.g., Lynch and Conery 2000; International Human Genome Sequencing Consortium 2004) and is probably due to the loss of (functional) duplicate copies over time.
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