Sentence examples for duplicates in the human from inspiring English sources
Using this rate, we would expect there to have been 1,188 new gene duplicates in the human genome since our split with chimpanzee (0.009 duplications/gene/my * 22,000 genes * 6 my).
Our analyses of putative young gene duplicates in the human genome have revealed both similarities and differences with other species.
Investigating the interplay between evolutionary forces and mutation in patterning the distribution of gene duplicates in the human genome might be of particular interest for several reasons.
Although, DNA-mediated events are responsible for the origin of the vast majority of young gene duplicates in the human genome, we identified ~11%% of duplicates as putatively originating from RNA-mediated events.
The high frequency of complete duplicates in the human genome is especially intriguing given that the length of human protein-coding genes is quite substantial with a mean and median length of 65 and 25 kb, respectively.
To date, there has been no systematic study in a strict evolutionary context that comprehensively characterizes the structural and genomic features of a large, unbiased population of evolutionarily young gene duplicates in the human genome.
A snapshot of a subclass file with FRT-like sequences sorted based on the sequence of their spacers is shown in Figure 4. To help identify FRT-like sequences with similar sequences patterns, we also grouped all 12,452 of the FRT-like sequences that have at least one exact duplicate in the human genome.
Not only are genes duplicated in the human and mouse lineages, but copy number variations (CNVs) are widely observed among human and mouse genomes.
Moreover, a subset of 4q35.2 sequences proximal and distal to the D4Z4 array, including the FRG1 and FRG2 genes, are duplicated in the human genome [ 4, 18, 19].
Genes that have not recently duplicated in the human lineage (since the human-mouse split) were examined for mouse lineage-specific duplication using data from the Ensembl Compara release 50 [ 25] from human (Homo sapiens) and mouse (Mus musculus).
