Exact(3)
Samples were tested in duplicate together with serum from 7 10 non-exposed United Kingdom or Melbourne donors.
Assays were performed in duplicate together with negative controls.
Samples were run in duplicate together with four tenfold serial dilutions (from 10to1010 transcript copy number) of the corresponding standard plasmid.
Similar(57)
Indeed an adjacency duplication means that two genes are duplicated together, while two nodes of an adjacency tree such that one is the descendant of the other and both are gene duplication events define a directed relation between the two duplications, even if they are not comparable from the gene trees (not in the same tree or not comparable in one tree).
Model 1 is appropriate for duplicated regions in which control regions are duplicated together with the coding sequence [ 35].
To test this prediction, we characterized the adjacent genomic regions for each vertebrate GATA locus, searching for examples of tightly linked loci that have been duplicated together as a result of whole chromosome duplications.
Through comparative genomics, we could find evidence that mkrn2 and mkrn4 have been duplicated together with other genes through a large-scale duplication.
Therefore it seems most likely that gchIa/b and socs4/5 precursors were duplicated together, possibly during one of the two earlier rounds of genome duplication having taken place during the early evolution of the vertebrate lineage (1R or 2R) [ 30, 47, 48].
In those cases, it has been postulated that the degenerative loss of regulatory modules in each of the two duplicates may have been sufficient to allow the preservation of the two genes, such that the duplicates together retain original functions of the single ancestor gene [5], [31].
The unusual structure of Nbs3-Rdg2a, in which sequences encoding part of the NB and the LRR regions are duplicated, together with the deletion of the region containing three complete LRR units in NB2-RDG2A relatove to RDG2A, provide further examples of variation at Rdg2 locus generated by recombination.
In the mouse the individual miRNAs of C2MC have been duplicated together with a B1F3 retrotransposon.
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