Receptor genes duplicate at random and the duplicated gene, unless it confers an adaptive advantage, then mutates at random.
STUDY DESIGN AND SETTING:Quality of reporting was asssessed according to the 26 items in the new guideline using a novel crowd sourcing methodology conducted independently and in duplicate, with random assignment, by 50 reviewers.
All samples were analyzed in duplicate, in random order and blinded to the clinical/pathological data.
The intraclass correlation coefficients between the blind duplicate (10% random sample) values ranged from 0.86 to 0.98 for HDL cholesterol, 0.86 to 0.98 for LDL cholesterol, and 0.88 to 0.99 for triglycerides.
The intraclass correlation coefficients between the blind duplicate (10% random sample) values ranged from 0.86 to 0.98 for HDL cholesterol, from 0.86 to 0.98 for LDL cholesterol, and from 0.88 to 0.99 for triglycerides.
For this, dried peptide samples were reconstituted in 30 μL of 25 mM ammonium bicarbonate, pH 7.8, and analyzed in duplicate and random order using identical chromatographic and electrospray conditions as for capillary LC-MS/MS analyses.
The intraclass correlation coefficients between the blind duplicate (10% random sample) values ranged from 0.87 to 0.99 for total cholesterol; 0.88 to 0.99 for triglycerides; 0.86 to 0.98 for LDL cholesterol; and 0.86 to 0.98 for HDL cholesterol.
Serum lipoprotein cholesterols were analyzed by using a combination of heparin-calcium precipitation and agar-agarose gel electrophoresis procedures (15).The intraclass correlation coefficients between the blind duplicate (10% random sample) values ranged from 0.86 to 0.98 for HDL-C, 0.86 to 0.98 for LDL cholesterol (LDL-C), and 0.88 to 0.99 for TGs (12, 14).
Deletions, translocations (either moving or duplicating a random segment into the bin), inversions and tandem duplications are simulated with equal probability.
