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The shape of the curve indicates how fast the library's complexity is being depleted, i.e., how the likelihood of a duplicate increases as sequencing continues.
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Sequencing in duplicate increased the average detection rate to >97%.
Therefore, the proportion of duplicated genes (summation of AS duplicates and no AS duplicates) increases as the identity criterion decreases.
The observation that structural divergence between WGD duplicates increases with time is consistent with this classical theory.
While the total number and fraction of genes with duplicates increases from simpler to more complex organisms, the propensity of duplicates to buffer against gene loss varies independently.
Furthermore, after the split from Nile tilapia, the difference in selection regimes on (TSGD) duplicates increases significantly, especially so for ar, ptk2b, and rac1a.
Expanding the P450 family, irrespective of the exact gene that is being duplicated, increases the range of substances which can be oxidatively altered.
Figure 1 B shows that the advantage increases as the number of gene duplicates increases in the Y, which may explain why the gene families in humans can be so large (mean copy number of 7).
As the score ratio decreased below 0.2, the false positive rate of duplicates increased.
The flattening of the socio-economic gradient in NHI-based hospitalisation rates suggests that either duplicates increased, and/or that the Census undercount increased, with socio-economic deprivation.
FAD mutants in which the APP gene is duplicated increase the gene dosage of APP by 50%, implying increased Aβ production [ 5].
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