The plot clearly shows that small negative studies are under-represented (fewer circles towards the bottom right of the graph in Figure 5A) and the use of the dummy studies to compensate for this deficiency.
This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether−lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly its hematological safety in glucose-6-phosphate dehydrogenase (G6PD) -deficient patients.
5. Baldari U, Righini MG, Raccagni AA, et al. Comparative double blind, double dummy study on the efficacy and safety of fluconazole 100 mg/day versus terbinafine 250 mg/day in the treatment of dermatomycoses.
The clear preference was seen in both treatment groups of this randomized, double-blind, double-dummy study, with respect to the other parameters of convenience, such as lifestyle fit and willingness to take for an extended period of time.
This can be performed in a blinded double dummy study, which is very difficult to design.
Researchers at the University of British Columbia recruited female undergraduates to participate in a dummy study, wherein they watched a video clip while eating M&Ms they had scooped into a bowl.
The trial was a 12-week multicentre, randomised, double-blind, double dummy study; 419 patients with moderate/severe COPD were randomised to BDP/FF 200/12 μg or FP/S 500/50 μg twice daily.
It had the title: "A randomised, multicentre, double-blind, double-dummy, parallel-group study to compare the efficacy and safety of subcutaneous sumatriptan with oral aspirin plus oral metoclopramide in the acute treatment of migraine" [7].
17 A summary of the primary and key secondary endpoints at week 33 is given in Table 3. Rascol et al conducted a randomized, double-blind, double-dummy, parallel-group study to assess efficacy, safety, and tolerability of an overnight switch from pramipexole IR to ER in early PD patients.
Assuming that these studies might not be properly controlled for extracorporeal device associated transient hypothermia, we performed the present study to analyze a dummy device effects on hemodynamics, body temperature and survival.
Based on preliminary pig studies with a model of total hepatectomy [ 11] and standardized intensive care therapy [ 18], we performed the presented study to evaluate a dummy device effects on hemodynamics, body temperature and survival.
