This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether−lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly its hematological safety in glucose-6-phosphate dehydrogenase (G6PD) -deficient patients.
The circles with squares around them, 30 in number, in Figure 5B indicate dummy studies invented by the trim and fill method to counteract bias.
In addition, double-dummy studies are difficult to execute, particularly with regard to dosing compliance.
This can be performed in a blinded double dummy study, which is very difficult to design.
Researchers at the University of British Columbia recruited female undergraduates to participate in a dummy study, wherein they watched a video clip while eating M&Ms they had scooped into a bowl.
The trial was a 12-week multicentre, randomised, double-blind, double dummy study; 419 patients with moderate/severe COPD were randomised to BDP/FF 200/12 μg or FP/S 500/50 μg twice daily.
5. Baldari U, Righini MG, Raccagni AA, et al. Comparative double blind, double dummy study on the efficacy and safety of fluconazole 100 mg/day versus terbinafine 250 mg/day in the treatment of dermatomycoses.
The clear preference was seen in both treatment groups of this randomized, double-blind, double-dummy study, with respect to the other parameters of convenience, such as lifestyle fit and willingness to take for an extended period of time.
It had the title: "A randomised, multicentre, double-blind, double-dummy, parallel-group study to compare the efficacy and safety of subcutaneous sumatriptan with oral aspirin plus oral metoclopramide in the acute treatment of migraine" [7].
17 A summary of the primary and key secondary endpoints at week 33 is given in Table 3. Rascol et al conducted a randomized, double-blind, double-dummy, parallel-group study to assess efficacy, safety, and tolerability of an overnight switch from pramipexole IR to ER in early PD patients.
