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Another approach to overcome the problem of the additive holiday dummy approach of Sect.
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The most promising methodology to deal with public holidays is the replacing public holiday dummy approach (model repH of Sect. 4.5).
This sort of "Shakespeare for Dummies" approach to staging has plagued theater companies for a while now.
Even though the hybrid model is motivated by the disadvantages of the additional holiday dummy approach we can use it with the replacing method as well.
There is no double-blind, double dummy approach (this was not allowed due to the size of the ticagrelor tablets, which cannot be neither inserted in capsules nor reduced to powder).
It includes the additional dummy and the replacing dummy approach.
The replacing dummy approach is able to overcome this problem.
In the replacing public holiday dummy approach, we add public holiday dummies to the model but set the weekday dummies at the holidays to zero.
Randomisation was by computer allocation and blinding was maintained using a double dummy approach.
The double-dummy approach guaranteed the blinding of medication during the trial and prevented any bias in terms of treatment decisions.
Thus, both SMI and MMI can be used to impute missing values on background variables in large-scale assessments to avoid the conceptual flaws and the possible biases associated with the common approach of dummy coding missing observations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com